求助Jpn Heart J(期刊名)文献1篇+Expert Opin Pharmacother. 文献1篇
【题名】：Is ACE gene polymorphism associated with lone atrial fibrillation?【作者】：Yamashita T, Hayami N, Ajiki K, Oikawa N, Sezaki K, Inoue M, Omata M, Murakawa Y.
【杂志名全称】：Japanese Heart Journal
【年, 卷(期), 起止页码】：Jpn Heart J. 1997 Sep;38(5):637-41.
【DOI】：
【全文链接】：[url]http://search.jamas.or.jp/link/ui/1998055477[/url]
【摘要信息】：ACE (angiotensin converting enzyme) gene genotypes have been shown to be a risk factor for development of left ventricular hypertrophy and cardiomyopathy, upon the assumption that the DD genotype is linked to higher cellular ACE activity leading to myocardial fibrosis. To test an analogous hypothesis that the DD genotype favors myocardial fibrosis in the atrium and thus promotes atrial fibrillation without any structural heart diseases, we determined the distribution of the ACE gene genotypes in 77 patients with lone atrial fibrillation and investigated the effects of the ACE genotypes on the clinical characteristics of atrial fibrillation. The distribution of ACE genotypes was not significantly different between the patients and healthy volunteers. Also, the ACE gene genotypes did not affect the types of atrial fibrillation and the age at the onset of atrial fibrillation. Thus, these results refuted the hypothesis of possible relationships between ACE genotypes and lone atrial fibrillation through myocardial fibrosis, and indicated some unknown differences between the atrium and ventricle.
PMID : 9462412 ISSN : 0021-4868 CODEN : JHEJAR
【题名】：Effect of angiotensin-converting enzyme insertion/deletion genotype on collagen type I synthesis and degradation in patients with atrial fibrillation and arterial hypertension.
【作者】：Tziakas DN, Chalikias GK, Stakos DA, Papazoglou D, Papanas N, Papatheodorou K, Chatzikyriakou SV, Kotsiou S, Maltezos E, Boudoulas H.
【杂志名全称】：Expert opinion on pharmacotherapy
【年, 卷(期), 起止页码】：2007 Oct;8(14):2225-34.
【DOI】：
【全文链接】：[url]http://informahealthcare.com/doi/abs/10.1517/14656566.8.14.2225%20[/url]
【摘要信息】：OBJECTIVE: The present study was undertaken to assess the impact of the angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) polymorphisms on circulating markers of collagen type I synthesis and degradation, and also to study the effect of therapy with ACE inhibitors on these markers in hypertensive patients with atrial fibrillation (AF). RESEARCH DESIGN AND METHODS: ACE I/D genotypes were assessed in 158 hypertensive patients (71 +/- 9 years; 72 male) with AF and 174 patients with arterial hypertension in sinus rhythm (SR) (71 +/- 9 years; 88 male). Serum concentrations of amino-terminal propeptide of pro-collagen type I (PINP) and of carboxy-terminal telopeptide of collagen type I (CITP), indices of collagen type I synthesis and degradation, respectively, were measured. RESULTS: Of the 332 study participants, 74 (22.3%) were I/I, 158 (47.6%) were I/D and 100 (30.1%) were D/D carriers. Genetic variation in ACE significantly influenced serum CITP levels in AF patients (p = 0.011). CITP levels were lower in D allele carriers (DD and ID) compared with I/I carriers. There was no difference in PINP levels between the different ACE genotype groups (p = 0.302). Patients treated with ACE inhibitors had higher CITP levels compared with those not treated (p = 0.036). CONCLUSIONS: This study suggests that the presence of the D allele in hypertensive patients with AF is associated with attenuation of type-I collagen degradation, and that therapy with ACE inhibitors increases degradation of collagen type I. The data indicate a subgroup of patients with AF and arterial hypertension who may benefit to a greater extent from therapy with ACE inhibitors, thus, providing a basis for pharmacogenetics.
[[i] 本帖最后由 bene 于 2010-7-26 10:21 编辑 [/i]] 给lz提供个链接，我是没权限的:lol
[url]http://search.jamas.or.jp/link/ui/1998055477[/url] 还是谢谢你 22 2ok
[url]http://u.115.com/file/f15ba64a0b[/url]
Effect_of_angiotensin-converting_enzyme_insertion_deletion_genotype_on_collagen_type_I_synthesis_and_degradation_in_patients_with_atrial_fibrillation_and_arterial_hypertension.pdf 谢谢 “ 20051234512345” 速度真快
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